Four of the top superstars in women’s college basketball are set to face off on the biggest stage.

Angel Reese and the defending-champion LSU Tigers will go up against leading National Player of the Year candidate Caitlin Clark and her Iowa Hawkeyes at the MVP Arena in Albany, New York.

Then, Paige Bueckers and the Connecticut Huskies will face off against top-ranked freshman JuJu Watkins and the USC Trojans at the Moda Center in Portland, Oregon.

Angel Reese and Caitlin Clark set for rematch in the Elite Eight

Reese and LSU are trying to defend the title that they won last year against Clark and Iowa. LSU has had a fairly dominant tournament this year, winning their previous three games by double-digits. Reese was named the Most Outstanding Player of last year's NCAA Tournament.

Clark, who became the NCAA’s all-time leading scorer this season, will try to lead Iowa to the Final Four and avenge last year's loss against LSU. Like the Tigers, the Hawkeyes have dominated their opponents in this year’s tournament run, beating each team by 10 or more points.

This star-studded matchup will surely be fiery considering the stakes and a little bit of history between these teams. Reese and Clark had some words for each other last year and have developed a rivalry.

JuJu Watkins, Paige Bueckers vie for Final Four spot 

Reese vs. Clark isn't the only star-studded matchup on tonight's game. Watkins vs. Bueckers will also be must-see TV. Watkins is making waves in March Madness as a freshman, while Bueckers is determined to prove she's still one of the best players in the nation.

Watkins, the sensational first-year player from USC, will try to lead the Trojans further into the Big Dance after just recently surviving a scare against the Baylor Bears in the Sweet Sixteen. Watkins has been the nation’s second-leading scorer, averaging over 27 points a game behind only the prolific Clark, but she will have her hands full against a UConn team that's led by legendary coach Geno Auriemma.

On the other hand, Bueckers and UConn aim to reclaim the glory that has evaded them for the past few seasons. Despite winning the NCAA Player of the Year award as a freshman and reaching the championship game that year, Bueckers has been plagued with knee injuries over her last two seasons. Now, she's hoping to show the world what she’s capable of again on the biggest stage.

All eyes will be on Watkins and Bueckers as they face each other for the first time and try to lead their respective teams to Cleveland for the Final Four.